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Antibacterial and anti-flaming PA6 composite with metathetically prepared nano AgCl@BaSO

Wei Zhang, Boren Xu, Caihong Gong, Chunwang Yi, Shen Zhang

《化学科学与工程前沿（英文）》 2021年 第15卷 第2期   页码 340-350 doi: 10.1007/s11705-020-1942-9

摘要： In this study, a facile and environmentally friendly method with low energy consumption for preparing nanoscale AgCl and BaSO co-precipitates (AgCl@BaSO co-precipitates) was developed based on the metathetical reaction. Then, the dried co-precipitates were melt-compounded with polyamide 6 (PA6) resins at a specified mass ratio in a twin-screw extruder. The results demonstrated that in the absence of any coating agent or carrier, the nanoparticles of AgCl@BaSO co-precipitates were homogeneously dispersed in the PA6 matrix. Further analysis showed that after the addition of AgCl@BaSO co-precipitates, the antibacterial performance, along with the flame-retardance and anti-dripping characteristics of PA6, was enhanced significantly. In addition, the PA6 composites possessed high spinnability in producing pre-oriented yarn.

关键词： nano AgCl@BaSO4 co-precipitates     antibacterial     flame resistance     PA6 composite     PA6 yarn    

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Preparation and rheological behaviors of PA6/SiO2 nanocompiste

WEI Shanshan, LIU Yuejun, LI Xianggang, HUANG Yugang, WANG Xiayu, ZHANG Ping

《化学科学与工程前沿（英文）》 2007年 第1卷 第4期   页码 332-337 doi: 10.1007/s11705-007-0060-2

摘要： The polyamide 6 (PA6)/SiO nanocomposites were prepared by in situ polymerization and the rheological behaviors were investigated. The morphology of resultant materials was characterized by scanning electron microscopy (SEM) and the rheological behaviors were characterized by capillary rheometer. The results showed that the SiO particle size was around 50 nm and the particles dispersed evenly in PA6 matrix. The nanocomposites were pesudoplastic fluids and the apparent viscosities of nanocomposites increased initially and then decreased with the increase in nano-SiO content at the same temperature. The non-Newtonian indexes of nanocomposites were smaller than those of pure PA6. With the increase in nano-SiO content the apparent viscous activation energies of nanocomposites increased initially and then decreased. The rheological behaviors revealed that there were strong interactions between PA6 macromolecule chains and nano-SiO particles.

关键词： polyamide     temperature     rheological     activation     pesudoplastic    

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A comprehensive analysis of a 3-P (Pa) S spatial parallel manipulator

Yuzhe LIU,Liping WANG,Jun WU,Jinsong WANG

《机械工程前沿（英文）》 2015年 第10卷 第1期   页码 7-19 doi: 10.1007/s11465-015-0324-3

摘要：

In this paper, a novel 3-degree of freedom (3-DOF) spatial parallel kinematic machine (PKM) is analyzed. The manipulator owns three main motions (two rotations and one translation) and three concomitant motions (one rotation and two translations). At first, the structure of this spatial PKM is simplified according to the characteristic of each limb. Secondly, the kinematics model of this spatial PKM is set up. In addition, the relationship between the main motions and concomitant motions is studied. The workspaces respectively based on the outputs and inputs are derived and analyzed. Furthermore, the velocity model is put forward. Two indexes based on the velocity model are employed to investigate the performance of this spatial PKM. At last, the output error model can be obtained and simulated. The comprehensive kinematics analysis in this paper is greatly useful for the future applications of this spatial PKM.

关键词： parallel mechanism     concomitant motions     kinematics     workspaces     error model    

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规模化制造芯鞘纱线基太阳能界面蒸发系统的供液调控和海水淡化性能 Article

肖杏芳, 潘露琪, 陈涛, 王满玉, 任李培, 陈贝, 王迎奥, 张骞, 徐卫林

《工程（英文）》 2023年 第30卷 第11期   页码 153-160 doi: 10.1016/j.eng.2023.03.015

摘要：

调控太阳能界面蒸发系统的供液量增强局域热效应是提高其效率的有效途径。然而，由于海水淡化过程中容易盐结晶导致阻塞，在控制供液量实现局域加热过程中存在结盐的临界点，在本研究中，利用简便、可尺寸化的编织技术制备了可调控供液速率的芯鞘结构基光热纱线，实现稳定、高效的太阳能界面蒸发同时防止盐结晶。芯-鞘结构纱线由莫代尔纤维作为芯，碳纤维作为鞘。由于芯-鞘的结构设计，在碳纤维内部的超亲水莫代尔纤维可实现高效的液体输送。芯鞘结构纱线中碳纤维将芯纱完全包裹覆盖使得其编织物在整个太阳光波段具有较高的吸光性（92%）。在一个太阳光（1 kW·m−2）下，通过调节芯鞘纱线内莫代尔纱线的股数，可以使此系统的蒸发速率达到2.12 kg·m−2·h−1，能量转换效率达93.7%。实际应用测试表明，此太阳能界面光热系统可以在5%（质量分数）的NaCl溶液中保持高效稳定的海水淡化性能。

关键词： 太阳能界面海水淡化     光热纱线     可调控供液     芯鞘纱     盐阻塞    

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微波辐射下离子液体［RMIm］PF6（R=P, B, C6）的合成及其电导率研究

何永福

《中国工程科学》 2008年 第10卷 第9期   页码 92-95

摘要： 1－溴己烷)在80 ℃回流加热10 min，可制得咪唑类离子液体的中间体溴代1－丁基－3－甲基咪唑（［BMIm］Br）、溴代1－丙基－3－甲基咪唑（［PMIm］Br）、溴代1－己基－3－甲基咪唑（［C6MIm］Br），进一步与HPF6在室温搅拌反应4 h，制得憎水性的咪唑类离子液体［BMIm］PF6，［PMIm］PF6和［C6MIm］PF6。

关键词： 离子液体     微波辐射     电导率     [BMIm]PF6     [PMIm]PF6     [C6MIm]PF6    

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Cytokine storm and translating IL-6 biology into effective treatments for COVID-19

《医学前沿（英文）》 doi: 10.1007/s11684-023-1044-4

摘要： As of May 3, 2023, the coronavirus disease 2019 (COVID-19) pandemic has resulted in more than 760 million confirmed cases and over 6.9 million deaths. Several patients have developed pneumonia, which can deteriorate into acute respiratory distress syndrome. The primary etiology may be attributed to cytokine storm, which is triggered by the excessive release of proinflammatory cytokines and subsequently leads to immune dysregulation. Considering that high levels of interleukin-6 (IL-6) have been detected in several highly pathogenic coronavirus-infected diseases, such as severe acute respiratory syndrome in 2002, the Middle East respiratory syndrome in 2012, and COVID-19, the IL-6 pathway has emerged as a key in the pathogenesis of this hyperinflammatory state. Thus, we review the history of cytokine storm and the process of targeting IL-6 signaling to elucidate the pivotal role played by tocilizumab in combating COVID-19.

关键词： SARS-CoV-2     COVID-19     cytokine storm     interleukin-6     tocilizumab    

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FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

《医学前沿（英文）》 2023年 第17卷 第4期   页码 714-728 doi: 10.1007/s11684-022-0959-5

摘要： FRMD6, a member of the 4.1 ezrin–radixin–moesin domain-containing protein family, has been reported to inhibit tumor progression in multiple cancers. Here, we demonstrate the involvement of FRMD6 in lung cancer progression. We find that FRMD6 is overexpressed in lung cancer tissues relative to in normal lung tissues. In addition, the enhanced expression of FRMD6 is associated with poor outcomes in patients with lung squamous cell carcinoma (n = 75, P = 0.0054) and lung adenocarcinoma (n = 94, P = 0.0330). Cell migration and proliferation in vitro and tumor formation in vivo are promoted by FRMD6 but are suppressed by the depletion of FRMD6. Mechanistically, FRMD6 interacts and colocalizes with mTOR and S6K, which are the key molecules of the mTOR signaling pathway. FRMD6 markedly enhances the interaction between mTOR and S6K, subsequently increasing the levels of endogenous pS6K and downstream pS6 in lung cancer cells. Furthermore, knocking out FRMD6 inhibits the activation of the mTOR signaling pathway in Frmd6−/− gene KO MEFs and mice. Altogether, our results show that FRMD6 contributes to lung cancer progression by activating the mTOR signaling pathway.

关键词： FRMD6     lung cancer     mTOR pathway    

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用于高风险环境安全监测和可调热管理的具有分层核壳结构的耐化学品纱线 Article

Duo Xu, Yingcun Liu, Can Ge, Chong Gao, Ze Chen, Ziyi Su, Haoran Gong, Weilin Xu, Jian Fang

《工程（英文）》 2024年 第32卷 第1期   页码 221-229 doi: 10.1016/j.eng.2023.06.018

摘要：

Chemical resistant textiles are vital for safeguarding humans against chemical hazards in various settings, such as industrial production, chemical accidents, laboratory activities, and road transportation. However, the ideal integration of chemical resistance, thermal and moisture management, and wearer condition monitoring in conventional chemically protective textiles remains challenging. Herein, the design, manufacturing, and use of stretchable hierarchical core–shell yarns (HCSYs) for integrated chemical resistance, moisture regulation, and smart sensing textiles are demonstrated. These yarns contain helically elastic spandex, wrapped silver-plated nylon, and surface-structured polytetrafluoroethylene (PTFE) yarns and are designed and manufactured based on a scalable fabrication process. In addition to their ideal chemical resistance performance, HCSYs can function as multifunctional stretchable electronics for real-time human motion monitoring and as the basic element of intelligent textiles. Furthermore, a desirable dynamic thermoregulation function is achieved by exploiting the fabric structure with stretching modulation. Our HCSYs may provide prospective opportunities for the future development of smart protective textiles with high durability, flexibility, and scalability.

关键词： Hierarchical core–shell structure     Chemical resistant yarn     Wearable strain sensor     Thermoregulation    

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基于单幅微距图像的布料丝线结构建模 Special Feature on Virtual Reality-Research Articl

Hong-yu WU, Xiao-wu CHEN, Chen-xu ZHANG, Bin ZHOU, Qin-ping ZHAO

《信息与电子工程前沿（英文）》 2019年 第20卷 第9期   页码 1165-1174 doi: 10.1631/FITEE.1800693

摘要： 真实世界的布料具有不同的微观丝线结构，导致不同布料具有各种各样外观。布料真实感绘制在影视制作、电子商务等领域具有重要应用价值。为获取布料微观丝线几何信息，传统方法需要微米CT扫描仪等昂贵复杂设备，并且采集过程费时费力，难以普及。为降低布料丝线获取复杂度，本文提出一种基于单幅微距图像的丝线获取与建模方法，仅需装有微距镜头的普通消费级相机拍摄的微距图像。该方法首先通过单幅微距图像的明暗信息获得丝线的大尺度几何；然后，通过丝线追踪算法获得丝线上的纤维细节；最后将这两者结合，得到布料丝线的微观尺度几何。实验结果表明，本方法能够高效获取各种类型布料丝线几何。

关键词： 单幅微距图像；丝线三维几何；布料外观    

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1,5-戊二胺的细菌合成及应用 Review

马伟超, 陈可泉, 李艳, 郝宁, 王昕, 欧阳平凯

《工程（英文）》 2017年 第3卷 第3期   页码 308-317 doi: 10.1016/J.ENG.2017.03.012

摘要：

1,5-戊二胺是一种广泛分布于原核和真核生物中的具有多种生物活性的天然多胺，正日益成为一种重要的工业化学品，并在多个领域展现出广泛的应用前景，特别是作为单体用于合成生物基聚酰胺。基于1,5-戊二胺的聚酰胺5X 具有优异的性能和环境友好特性，因而有广泛的应用前景。本文总结了近期关于1,5-戊二胺在细菌中的生物合成、代谢及生理学功能，着重介绍了1,5-戊二胺在大肠杆菌的代谢调控机制。文中还综述了微生物发酵法和全细胞催化法生产1,5-戊二胺的进展及1,5-戊二胺的分离纯化方法。此外，对1,5-戊二胺在生物基聚酰胺合成中的应用进行了总结，并对利用可再生资源生产1,5-戊二胺进行了展望和对以后的研究提出了建议。

关键词： 1     5-戊二胺     代谢     细菌生产     生物基聚酰胺     PA 5X    

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RNA m6A modification and its function in diseases

null

《医学前沿（英文）》 2018年 第12卷 第4期   页码 481-489 doi: 10.1007/s11684-018-0654-8

摘要：

N6-methyladenosine (m6A) is the most common post-transcriptional RNA modification throughout the transcriptome, affecting fundamental aspects of RNA metabolism. m6A modification could be installed by m6A “writers” composed of core catalytic components (METTL3/METTL14/WTAP) and newly defined regulators and removed by m6A “erasers” (FTO and ALKBH5). The function of m6A is executed by m6A “readers” that bind to m6A directly (YTH domain-containing proteins, eIF3 and IGF2BPs) or indirectly (HNRNPA2B1). In the past few years, advances in m6A modulators (“writers,” “erasers,” and “readers”) have remarkably renewed our understanding of the function and regulation of m6A in different cells under normal or disease conditions. However, the mechanism and the regulatory network of m6A are still largely unknown. Moreover, investigations of the m6A physiological roles in human diseases are limited. In this review, we summarize the recent advances in m6A research and highlight the functional relevance and importance of m6A modification in in vitro cell lines, in physiological contexts, and in cancers.

关键词： RNA modification     m6A     immunity     cancer     epigenetics    

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A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodesthe candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors

《医学前沿（英文）》 2023年 第17卷 第3期   页码 458-475 doi: 10.1007/s11684-022-0968-4

摘要： The Ly-6 and uPAR (LU) domain-containing proteins represent a large family of cell-surface markers. In particular, mouse Ly-6A/Sca-1 is a widely used marker for various stem cells; however, its human ortholog is missing. In this study, based on a systematic survey and comparative genomic study of mouse and human LU domain-containing proteins, we identified a previously unannotated human gene encoding the candidate ortholog of mouse Ly-6A/Sca-1. This gene, hereby named LY6A, reversely overlaps with a lncRNA gene in the majority of exonic sequences. We found that LY6A is aberrantly expressed in pituitary tumors, but not in normal pituitary tissues, and may contribute to tumorigenesis. Similar to mouse Ly-6A/Sca-1, human LY6A is also upregulated by interferon, suggesting a conserved transcriptional regulatory mechanism between humans and mice. We cloned the full-length LY6A cDNA, whose encoded protein sequence, domain architecture, and exon‒intron structures are all well conserved with mouse Ly-6A/Sca-1. Ectopic expression of the LY6A protein in cells demonstrates that it acts the same as mouse Ly-6A/Sca-1 in their processing and glycosylphosphatidylinositol anchoring to the cell membrane. Collectively, these studies unveil a novel human gene encoding a candidate biomarker and provide an interesting model gene for studying gene regulatory and evolutionary mechanisms.

关键词： LU domain-containing protein family     novel human gene     LY6A     pituitary tumor     biomarker     nonsynonymous SNP     GPI-anchored protein    

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A rolling 6U parallel mechanism

Zhihuai MIAO, Yanan YAO

《机械工程前沿（英文）》 2011年 第6卷 第1期   页码 96-98 doi: 10.1007/s11465-011-0214-2

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抗静电增强尼龙66研制

刘建强

《中国工程科学》 2004年 第6卷 第6期   页码 77-78

摘要：

以阴离子和非离子型抗静电剂组成复合抗静电体系，用玻璃纤维为增强剂，研制成具有良好抗静电和机械性能优良的尼龙66；介绍了抗静电复合体系及玻璃纤维含量对抗静电增强尼龙性能的影响。

关键词： 尼龙66树脂     抗静电     增强剂    

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G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma

Wenjing Wang, Shigang Ding, Hejun Zhang, Jun Li, Jun Zhan, Hongquan Zhang

《医学前沿（英文）》 2019年 第13卷 第4期   页码 482-491 doi: 10.1007/s11684-018-0633-0

摘要： LGR6 is a member of the G protein-coupled receptor family that plays a tumor-suppressive role in colon cancer. However, the relationship between LGR6 expression in patients and clinicopathological factors remains unclear. This study aimed to clarify whether the expression level of LGR6 is correlated with colon adenocarcinoma progression. Immunohistochemistry was used to detect LGR6 expression in colon adenoma tissues ( = 21), colon adenocarcinoma tissues ( = 156), and adjacent normal tissues ( = 124). The expression levels of LGR6 in colon adenoma and adenocarcinoma were significantly higher than those in normal colon epithelial tissues ( <0.001). Low LGR6 expression predicted a short overall survival in patients with colon adenocarcinoma (log-rank test, = 0.016). Univariate and multivariate survival analyses showed that, in addition to N and M classification, LGR6 expression served as an independent prognostic factor. Thus, low expression of LGR6 can be used as an independent prognostic parameter in patients with colon adenocarcinoma.

关键词： LGR6     colon adenocarcinoma     immunohistochemistry     prognosis    

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标题 作者 时间 类型 操作

Antibacterial and anti-flaming PA6 composite with metathetically prepared nano AgCl@BaSO

Wei Zhang, Boren Xu, Caihong Gong, Chunwang Yi, Shen Zhang

期刊论文

Preparation and rheological behaviors of PA6/SiO2 nanocompiste

WEI Shanshan, LIU Yuejun, LI Xianggang, HUANG Yugang, WANG Xiayu, ZHANG Ping

期刊论文

A comprehensive analysis of a 3-P (Pa) S spatial parallel manipulator

Yuzhe LIU,Liping WANG,Jun WU,Jinsong WANG

期刊论文

规模化制造芯鞘纱线基太阳能界面蒸发系统的供液调控和海水淡化性能

肖杏芳, 潘露琪, 陈涛, 王满玉, 任李培, 陈贝, 王迎奥, 张骞, 徐卫林

期刊论文

微波辐射下离子液体［RMIm］PF6（R=P, B, C6）的合成及其电导率研究

何永福

期刊论文

Cytokine storm and translating IL-6 biology into effective treatments for COVID-19

期刊论文

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

期刊论文

用于高风险环境安全监测和可调热管理的具有分层核壳结构的耐化学品纱线

Duo Xu, Yingcun Liu, Can Ge, Chong Gao, Ze Chen, Ziyi Su, Haoran Gong, Weilin Xu, Jian Fang

期刊论文

基于单幅微距图像的布料丝线结构建模

Hong-yu WU, Xiao-wu CHEN, Chen-xu ZHANG, Bin ZHOU, Qin-ping ZHAO

期刊论文

1,5-戊二胺的细菌合成及应用

马伟超, 陈可泉, 李艳, 郝宁, 王昕, 欧阳平凯

期刊论文

RNA m6A modification and its function in diseases

null

期刊论文

A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodesthe candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors

期刊论文

A rolling 6U parallel mechanism

Zhihuai MIAO, Yanan YAO

期刊论文

抗静电增强尼龙66研制

刘建强

期刊论文

G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma

Wenjing Wang, Shigang Ding, Hejun Zhang, Jun Li, Jun Zhan, Hongquan Zhang

期刊论文